Italy is a compact, easily navigable country and its small size makes it ideal for multi-city and multi-centre holidays. You could visit the ancient relics in Rome before heading to the sunny shores of Sorrento on Naples' coastline, or venture further along the Amalfi Coast for a classic coastal getaway.
Or, start in the scenic countryside of Tuscany and enjoy its fabled cuisine before journeying to historic Florence and admiring its wealth of architectural and artistic monuments on a cultural holiday.
If style is more your speed, indulge in fashionable Milan, a shoppers paradise, before heading north to the stunning mountain scenery of the Italian Lakes or head east to romantic Venice or Verona, home of Shakespeare's Romeo and Juliet.
Here are just some of the city combinations you can explore on a luxurious, tailor-made Italian holiday with Wexas:
Rome and Sorrento
Rome, Italy's magnificent capital city, needs no introduction. You can explore its range of Roman monuments - such as the Pantheon and Coliseum - as well as Vatican City's famous Sistine Chapel and St Peter's Basilica in a few days before driving the scenic coastal roads around Naples to Sorrento's lush valleys and mountains.
From Sorrento it's just a short journey off the shoreline to the island of Capri or a 40-minute drive north to Pompeii.
Rome and Florence
Combining Rome and Florence is an artists dream come true. Visit the painted frescoes of the Sistine Chapel in the Vatican City in Rome and the archaeological works of art in the Piazza Navona and Piazza di Spagna before travelling just three hours to Florence.
In Florence admire Michealangelo's statue of David and the works of art in Galleria degli Uffizi and head out of the city centre to see the magnificent Medici Villas, which are scattered throughout the Tuscan countryside.
Tuscany: Florence and Siena
Explore the Tuscany Region's undulating rural landscapes and delectable cuisine with a visit to its capital, the Renaissance masterpiece of Florence, and see art from Michelangelo, Botticelli and Leonardo da Vinci before driving through the Chianti Wine Region to the medieval town of Siena, just a short distance away.
Milan and The Italian Lakes
Take a tour of Italy's fashion capital, glamorous Milan. See Leonardo da Vinci's famous painting, The Last Supper, in Milan's marble cathedral and sample the hustle and bustle of the busy city centre before heading north to the peaceful scenery of the Italian Lakes.
Milan and Venice
Shop until you drop on Milan's Quadrilatero d'Oro (golden quad), home of the flagship stores of Gucci, Versace, Prada and Dolce and Gabbana. Soak up the city's vibrant, cosmopolitan atmosphere before driving a coupe of hours to Venice, Italy's floating treasure.
Cross one of Venice's countless bridges and wander its 118 islands and take a gondola boat trip up the Grand Canal in this romantic city or relax on the beaches of The Lido.